Top Cancer Researcher Fails to Disclose Corporate Financial Ties in Major Research Journals

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Board of Directors

■ Aura Biosciences* (cancer startup)

■ Bristol-Myers Squibb

■ Foghorn Therapeutics (cancer startup)

■ Grail* (cancer testing startup)

■ Infinity Pharmaceuticals* (cancer startup)

■ Varian Medical Systems (radiation equipment)

 

Scientific or Clinical Advisory Board

■ ApoGen Biotechnologies (cancer startup)

■ Aura Biosciences (cancer startup)

■ Grail (cancer testing startup)

■ Juno Therapeutics*

■ Northern Biologics (cancer startup)

■ Paige.AI (pathology startup)

■ Peptomyc* (cancer startup)

■ PMV Pharmaceuticals (cancer startup)

■ Seragon Pharmaceuticals* (breast cancer)

 

Founder or Co-Founder

■ Mosaic Biomedicals*

■ Tango Therapeutics (cancer startup)

 

Paid Consultant

■ AstraZeneca*

■ Eli Lilly*

■ Novartis*

■ Roche/Genentech*

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Mystery in a Small Town: A Quiet Couple Shot Dead, Their Daughter Missing

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Since the murders, Ms. Jenderny said she spent $700 on a new alarm system and new outdoor lights that stay on all night. Her 8-year-old son now sleeps with her older son, 13. “He’s afraid to use the bathroom at night,” Ms. Jenderny said.

Longtime residents like the Closses have been joined in Barron over the last decade by refugees, many of them Somalis, who were drawn by jobs cleaning cages and slaughtering birds at the Jennie-O plant. These days, according to the mayor’s office, about 20 percent of residents have Somali heritage.

Not long after the killings and Jayme’s disappearance, members of the Somali community delivered trays of East African food to the sheriff’s office; the food was part of a flood of meals donated by residents and businesses to the officials working on the case.

“When we see in the U.S.A. the same things that we had back in our home, you fear,” said Kaltuma Hassan, 44, who was born in Somalia. She sat in the cafe she owns, Amin Restaurant, sharing dinner from a communal bowl with two of her children. “What if my children are next?”

As she spoke, her daughter, Najma Rashid, 10, stopped eating, clutched her stomach and cried out. “I’m scared!” she said. Her mother grabbed her hands. “I’m here for you.”

The investigation itself has fueled the unease here, several people said. Residents obsessively check the sheriff’s Facebook page for updates. Early on, the department asked residents to watch their neighbors for suspicious behavior. “People may act differently shortly after committing a violent act,” one post read.

Last week, a local man, Kyle Jaenke-Annis, was arrested inside the Closses’ house; officials said he had taken clothing, including underwear, that belonged to Jayme, but they also said he had been cleared of involvement in the killings and disappearance.

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Olivia Colman: Uneasy Lies the Head That Wears the Crowns

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LONDON — Olivia Colman does not have a process. She is apologetic, since she understands that this makes for uninteresting conversation about the many fascinating characters she has played — most recently the imperious, needy, vulnerable, monstrous Queen Anne in Yorgos Lanthimos’s “The Favourite,” for which she is hotly tipped as a best actress Academy Award nominee.

“I’m really sorry,” she said, squirming slightly, during a recent interview at a London hotel. “Let me think.” She brightened up. “I ate a lot to put on weight,” she said. “Does that count?”

Colman, 44, is unshowily famous in her native Britain, where she is known both as a comedy stalwart (“Peep Show”) and as a forceful dramatic actor (“Tyrannosaur”). She is fairly often described as a national treasure, so there was general rejoicing when it was announced that Colman would take over the role of Queen Elizabeth II from Claire Foy in coming seasons of the Netflix series “The Crown.”

Until now, she has been relatively unknown in the United States (although connoisseurs of prestige British television will know her from “Broadchurch” and “The Night Manager”). As she points out, she has never been the type to be cast in glossy leading lady roles. But “The Favourite,” which premieres Nov. 23, bagged the Silver Lion Grand Jury prize at the Venice Film Festival, won Colman the best actress award and has already garnered serious Oscar chatter, dragging her squarely into the spotlight even before her coming star turn in “The Crown.”

[Read our review of “The Favourite,” a critic’s pick.]

The spotlight is not where she likes to be. “I hate the loss of anonymity,” she said. “No one teaches you how to deal with that. I now just tend to stay home because it’s so weird not to be on an equal footing with people. They know your face, and you don’t know them.”

“It’s not that people aren’t lovely,” she added, “but it’s harder to deal with than you imagine.”

Colman is the most ordinary extraordinary person you have ever met. She is smiley, charming, apologizes frequently and plays down her talents at every opportunity. Her colleagues trip over their words trying to find enough adjectives to describe her likability, decency, kindness, her friendliness to the entire crew on any shoot, her lack of diva-dom. After several attempts at describing how much she adored Colman, Emma Stone — one of her co-stars in “The Favourite” — gave up. “You can tell I’m in love with her,” she said. Rachel Weisz, her other co-star, described her as “a proper delight — and with a very filthy sense of humor.”

But Colman has no trouble being less than lovable on screen. In Paddy Considine’s “Tyrannosaur,” she played a meekly religious, abused wife; in “Fleabag” a hilariously poisonous stepmother; in “Run,” a tough-as-nails inner city mother; in “Broadchurch” she was an often tearful, often irritable, willfully unglamorous police officer.

She also seems to have little vanity about how she is perceived. For the role of Queen Anne, where she is frequently shown in deliberately unflattering scenes, she put on 35 pounds without a murmur.

“I much prefer these sorts of roles because there is no pressure to be something you are not, and I am obviously not glamorous,” Colman said. (In fact, in the wake of a photo shoot, she did look glamorous, dressed in a belted black dress, high heels and long earrings. “I’m more a jeans and sweater-with-something-spilled-on-it person,” she said as she arrived.)

“For Anne, I wasn’t meant to look nice or be nice, and it was liberating and brilliant,” she said. “I find it more embarrassing to try to look good. I think I’ve been fortunate to be cast in these roles, because it’s very difficult for young women or men who are seen in one way, and then they are not allowed to age.”

In “The Favourite,” Colman’s Anne is jowly, lumbering and capricious; a willful child-woman who screams for attention and vulnerably displays her chronic insecurity and the deep unhappiness occasioned by losing 17 children to miscarriages, stillbirth and childhood death. Anne ruled from 1702-14, during a turbulent period that saw the incorporation of Scotland and England into the single state known as Great Britain, and the country’s long involvement in the War of the Spanish Succession. But the movie focuses on politics only to the extent that they influence the stratagems of the Duchess of Marlborough (Weisz) and her cousin Abigail Hill (Stone) as they scheme for the favors (all of them) of the Queen.

In a telephone interview, Lanthimos said that after seeing Colman’s performance in “Tyrannosaur” and working with her on “The Lobster,” he couldn’t think of anyone else to play Anne, and had shifted the schedule to accommodate her.

“I don’t think I would have made the film without her,” he said. “That role is quite difficult, quite complex. It needed a lot of different qualities from an actor, the ability to alternate between different states at different times. It has a lot to do with instinct. She reads the lines and goes to the right place without thinking about it too much.”

Colman says she doesn’t think about it at all. She hates rehearsal periods when actors and directors break down the script and motivation. “For me, when I really love a script, it’s visceral,” she said. “I can’t explain why, but I feel it; I want to say those words, be that person.”

Growing up in the city of Norwich, in the east of England, Colman said she dreamed of being an actor from a young age, but “it was a secret dream, like talking to animals.” Instead, she went to teacher training college in Cambridge, where she successfully auditioned for Footlights, an amateur dramatic club run by Cambridge University. There she met her future husband, Ed Sinclair (with whom she has three children), and followed him a year later to the Bristol Old Vic drama school.

After graduating in 1999 she went to countless auditions and didn’t get a single job for a year. “My mum had said, ‘You’ll probably give it a year.’ And I said, ‘No, I’ll give it 10 years,’” Colman said, betraying a smattering of steely resolve. A trickle of bit parts followed. She worked as a secretary — “not a very good one, although I was cheery” — and a cleaner. Although discouraged, she never thought of giving up. “I never wanted to do anything else,” she said. Then with sincere Colmanesque self-deprecation: “Also, I’m no good at anything else.”

Her breakthrough came in 2003, when David Mitchell and Robert Webb, fellow actors at Footlights, asked her to play a central role in “Peep Show,” a series that developed a cult following over nine seasons. Her talent for deadpan comedy didn’t go unnoticed, and Colman began to pick up bigger roles, mostly in sitcoms and comedies.

Tyrannosaur,” the first feature film directed by Mr. Considine, an actor, changed everything for Colman, who was cast as a physically and psychologically abused wife who forms an unlikely friendship with a violent widower. “I always wanted to do these kinds of dramatic roles, and I always knew that no one saw me that way,” Colman said. “Good old Paddy.”

That led to “Broadchurch,” and the role of Detective Sergeant Ellie Miller, one of the lead investigators (alongside David Tennant’s Detective Inspector Hardy) in a search for the killer of an 11-year-old boy. The series was a huge success in Britain and abroad, and even though Tennant was the bigger name, Coleman’s portrayal of a woman enduring the harrowing personal consequences of the investigation made the series hers.

Jodie Whittaker (“Doctor Who”), who played the bereaved mother Beth, Ellie’s best friend, said that Colman was “one of the only actors who can make you laugh and cry at the same time.”

“She brings such humor and vulnerability and playfulness to everything,” she said.

Colman has subsequently starred in several large-scale projects, notably “The Night Manager” (for which she won a Golden Globe) and the coming BBC production of “Les Misérables.” But the call from “The Crown” still came as a shock, she said.

“I was such a massive fan of the show, and I thought Claire Foy was just breathtaking,” she said. “I no idea they were going to recast for season 3 and 4, so hadn’t thought about the role at all.” She did an imitation of her agent calling her and trying to be discreet while she shrieked “the Queen?!” with her phone on loudspeaker.

Remembering the first meeting with the producers, she laughed. “I was very uncool when I went to meet them,” she said. “I just said, ‘Oh yes please,’ and they were totally taken aback.” The role of the young queen brought Foy a Golden Globe and an Emmy, among other awards, and international fame. It was hard to imagine filling her shoes, Colman said; her solution is not to think about it and “just plow on.”

But her no-process approach had to be modified here, she admitted. “The research department is a massive operation,” Colman explained. “I absorb best through watching videos, and I’ve spent hours and hours doing that.” She has also spent a great deal of time with voice coaches perfecting the queen’s voice and accent, and with a movement coach who has helped her master a particular posture and way of walking. “I walk a bit like a farmer, not a queen, and I’m not a very good physical impersonator,” Colman said. “So there is a dollop of artistic license.”

In 15 years Colman has moved from the broad comedy of “Peep Show” to the high seriousness of “The Crown,” and rumors of an Academy Award nomination for “The Favourite.” “I don’t know what to do with it,” she said. “Talking about the Oscars seems like a silly dream. If you wake up one day and it hasn’t happened, you’ll be cross for feeling disappointed.” Colman seems constitutionally wired for disappointment avoidance. “I still worry that I won’t have work,” she said, adding that she felt she should make hay before it all went to hell. (She used a stronger word than hell.)

She made a series of impressively unregal grimaces, eyes widening, mouth pulling down, nose wrinkling. “You know,” she said Englishly, “don’t behave badly; they may not ask you back.”

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The 52 Places Traveler: A Night Out in Kigali

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Angeline wasn’t the only family member to move back. I met new transplants from Boston and New Orleans, as well as Annabelle Uwera, who may be the pioneer of the bunch. She’s about to celebrate a decade back, after 10 years in London, and is now a super-plugged-in trade officer for the British High Commission.

I felt the sense of safety that Angeline had mentioned. I took walks alone at night and even hopped on a few motorcycle taxis to get around. (They’re 10 times cheaper than regular taxis, and thrilling to ride.) As M.A. explained, the government changed the constitution to ensure women feel less vulnerable, after the horrific rapes of 1994. “Women can have the power to do anything they want. They can say ‘no’. And men know they can’t beat you. They know if they do something wrong, they will go to jail.”

There is a dark side to the sense of opportunity. Adult men over the age of 35 are largely dead and gone; two generations were wiped out in three months. “One of the consequences of genocide is we have a lot of young people and a lot of women,” said Serge Kamuhinda, another family member, and a Volkswagen executive, who grew up in Germany after fleeing Rwanda at age 12. He remembers his village in flames and people running at him with machetes.

Then there are the critics of the government who have left the country for fear of political persecution, or who fled during the genocide and still feel unsafe coming home. Certain topics — politics, ethnic identity — are rarely discussed.

The people I met in Kigali do talk about the genocide, though, and often. It comes up in the fabric of everyday conversation as something that changed their country so distinctly that there is only a before and after. Almost everyone you meet has suffered loss and trauma. M.A. and Angeline lost their grandparents, uncles, aunts and cousins.

Annabelle, from London, encouraged me to go to the city’s powerful Kigali Genocide Memorial to better understand the history. When I later told her I had cried in the Children’s Room, which features portraits of kids as young as 15 months who were burned alive or had their skulls bashed in, she told me that she cannot go into that room. She has relatives in there.

Still, for every one of my new friends that night at Pili Pili, the rewards of being together with their remaining loved ones in the country that is their home seemed to far outweigh the possibility of being re-traumatized, or the fact that they all had to take massive pay cuts to move back from overseas.

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The 52 Places Traveler: On an Icelandic Road Trip, Mossy Moonscapes and More

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Yuan: Agreed on Braud & Co. — but you’re forgetting all the pizza! I thought some of it was pretty good. I’m sorry you didn’t get to eat dinner at KEX Hostel, where we stayed. Their arctic char (2350 krona) was delicious and relatively affordable, and the breakfast buffet (1690 krona in advance and 1990 krona the day of) easily ranks as one of the top three of my trip so far. Mostly, I remember thinking, Lucas is very dinner-focused — which I now realize was an asset. If you’re not paying attention to time, suddenly it’s 9 p.m. and every rural restaurant is closed and your evening meal is leftover chips from a hotel party — which happened to us.

Because not a lot grows on Iceland, I’d stick with things with limited imported ingredients, including skyr (like yogurt, but milder), baked goods, fish and soup.

Peterson: I remember that soup: all-you-can-eat mushroom soup and bread for 1,000 krona at Cafe Riis. A little salty, but unquestionably the best deal we found.

Peterson: Driving in Iceland is an adventure, and mostly a pleasure — especially along the less-trafficked northern coastal route we took. The roads alternate between well-maintained to unpaved and barely there — with sometimes little warning when that might occur. We rented a four-wheel-drive vehicle, which I would recommend (but remember that off-road driving is illegal). Our car also had a manual transmission, which was fine for us, but may not work for some drivers. You can get an automatic, but be prepared to shell out extra money for it.

Yuan: I wish you had been there when the rental counter guys handed me a pamphlet titled “Driving in Iceland is different” with scary pictures of ways the car could get damaged: one-lane bridges, sheep crossings. Usually, I just go with the insurance provided by my credit card. I’m so glad you talked me into buying everything available, including coverage for rocks hitting our windshield. It’s important: In the remote north, a rock hit the car being driven by our videographers, Tim and Veda, and had to be towed four hours back to Reykjavik.

But, man, did I love driving there. After you left, I did a bus tour of “Game of Thrones” locations. While I loved nerding out with my guide, Raven, who wore a Man of the Night’s Watch outfit and reenacted a sword fight with a wedding party we happened upon, it was stifling not to be able to pull over on a whim. I had to drive around for hours afterward just to get it out of my system.

Peterson: I was astounded to learn how quickly tourism has grown in Iceland over the past 10 years, thanks in part to dirt-cheap fares from airlines like WOW Air: from 485,000 foreign visitors in 2007 to over 2.2 million in 2017. It’s had a big impact on the local populace, too. One evening, after dinner at the restaurant Egill Jacobsen, we headed upstairs to a chic bar called Loftid, decked out with Edison bulbs and vintage sewing paraphernalia.

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Marriott Hack Adds Passport Headache, but Its Intensity Is in Dispute

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It has become a familiar dance: A company reports a data breach, and you dutifully change your passwords, ask for a new credit card and hope your information doesn’t end up for sale on the dark web. But the hack that last week engulfed Marriott — and 500 million of its customers — has added a new step: Your passport might be at risk, too.

Whether those customers should go get a new passport is perhaps the most complicated consumer question hanging out there in the wake of the news that millions of Starwood Hotels customers had their data stolen in a breach that began as early as 2014. Brands like Westin, Sheraton, Aloft and W are affected, but not Marriott brands that predate the company’s acquisition of Starwood in 2016.

Besides passport information, the thieves took names, addresses, dates of birth, and credit or debit card numbers, though it’s possible that they did not get access to every bit of information for each person in the company database.

Given how often bank card fraud occurs, Starwood customers may have obtained a new number in the past few years, anyway.

But a subset of Starwood customers — those who traveled abroad and had to turn over their passport numbers at the check-in desk — face a question that few breach victims have faced before: What is the likelihood that someone might use that number to acquire a new passport and use it for no good?

[After almost two months of picket lines, Marriott workers have agreed to a settlement.]

The State Department says there isn’t much of a chance. The World Privacy Forum and the Identity Theft Resource Center say there is — with a mild qualification. If you’re among the Starwood customers who had to hand over passport information, your decision will hang on your taste for the very long odds of very bad people doing horrible things with a passport they acquired in your name.

The thieves — the hackers have not been identified, but the stolen information has not turned up on the dark web, which experts said suggested the work of a state actor — were able to access passport numbers because local or national rules sometimes require hotels to collect them. Depending on where you go in the world, officials in the place you are visiting may require your hotel to examine your passport and perhaps transmit passport information to local authorities.

It is unclear how long Marriott had held on to the information and if it held it longer than it had to. A spokeswoman said the company was not certain about these details yet.

A Hilton spokesman said that when its hotels are required to gather passport information, they often upload it via third-party software to the relevant authorities. The length of time such information is retained depends on the location of the hotel. A Hyatt spokeswoman said that it collects the minimum amount of personal information necessary to provide services that guests say they want or to comply with local rules.

It is also not clear how many former Starwood customers have a decision to make about their passports. A Marriott spokeswoman would only say that it believed that the number would be a “very small subset” of the larger group but that it did not have a precise number just yet. But even a small subset of 500 million can be a very big number: If two-tenths of a percent of customers are affected, that would be one million people.

The State Department does not believe those people need new passports. The logic goes like this: Nobody can access your travel records using a passport number, nor can anyone travel in your name simply by presenting those digits. If the thieves try to obtain a replacement in your name, they’ll run into difficulty: Unable to present a lost or expired passport, they would need a sheaf of other documents to prove that they are you.

But that’s where the danger lies, said Pam Dixon, executive director of the World Privacy Forum. Sophisticated thieves can clear those hurdles, she said.

“The Marriott breach is risky precisely because they had the passport number plus all of the demographic information,” she said of the thieves. She worried in particular about an emerging form of fraud called “morphing” — in which determined thieves create fake supporting documents and then try to obtain a passport in your name. Part of the process involves creating an image by merging a photo of you that they find online with a photo of a thief — similar to the “deepfake” videos that can already be found on the internet.

Ms. Dixon said she would replace her passport once she finished a pending trip abroad. Eva Velasquez, president of the Identity Theft Resource Center, said that she would do the same if she received notification from Marriott indicating that thieves retrieved useful information like her address and date of birth in addition to her passport number. (Marriott is just beginning the process of informing customers if their data is on the loose.)

To be clear: Thieves probably won’t be making a few million passports. For any one person to become a victim, the thieves would need to be in the business of faking identities in the first place. That may not be their endgame at all. Then, they’d have to pick on your data and be successful in getting a passport in your name. Then, they’d have to choose to use it.

The odds of all that happening are low. In the world of payment cards — where fraud is not nearly as complicated — it’s still a small portion of customers that have to deal with it. A Visa spokeswoman said that as its algorithms improved and companies became more sophisticated, it has seen fraud rates on at-risk card accounts falling below 5 percent.

That won’t keep some people from wanting to do anything they can to avoid even rock-bottom odds of, say, landing in jail when they try to enter another country someday. So they’ll get a new passport, which comes with a new passport number.

For now, Marriott doesn’t want to pay for that peace of mind. Instead, it’s setting up a process to work with guests who may one day experience passport fraud that they believe was a result of this breach. Then and only then will it reimburse people for the costs involved with getting a new passport. On Sunday, Senator Chuck Schumer, Democrat of New York, called on the company to reimburse people who choose to obtain new passports.

Marriott is offering customers free enrollment in a service called Web Watcher from the security company Kroll, which scans the dark web for information that thieves may be trying to sell. You can give the service your passport number and ask it to watch out for those figures out there in the blackness — but the membership expires after a year.

But breach anxiety can be forever, or at least 10 years: the standard renewal period for adults’ passports.

So why can’t a company, just once, say something like the following? “We’re sorry. And we’re going to protect you for as long as you feel like you need protecting.”

Stacy Cowley contributed reporting.

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